Where should we put the most important content in a document, options in a software UI, or elements on a web page?
Below is a heatmap of my mouse pointer over 4 hours of general computer usage. It should give you an idea of where I work on my screen (22″ LCD). It would not be much different for other users, doing casual tasks on any which monitor.
A far better (and more scientific) study to answer the question above would be eye tracking. So then why am I talking about mouse heatmap? Not everyone gets to conduct an eye tracking study. My intention behind promoting this is for us to get a first-hand idea of the fact that screen real estate is partially and more importantly selectively used. So use it optimally to communicate.